Fetal Bovine (Calf) Serum (FBS or FCS), is a nutrient-rich fluid derived from the blood of bovine fetuses- but does not contain red blood cells or other clotting components. FBS has excellent cell growth characteristics, low endotoxin, low hemoglobin values and is ideal for research that is reliant on growth of cell lines.
Each batch of serum meets the USDA standards for animal products, Biologos’ standard for raw materials, is traceable to date and collection location, and is processed using:
- Sterile filtering
- Heat inactivation
FBS applications include, but are not limited to:
FBS0100 - Fetal Bovine Serum
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About Fetal Bovine Serum (FBS)
What is FBS?
Fetal Bovine Serum (FBS), is a nutrient-rich fluid derived from the blood of bovine fetuses- but does not contain red blood cells or other clotting components. FBS is composed of bovine serum albumin (BSA), a globular-protein and other proteins that support the growth, survival, and division of cultured cells.
How is Fetal Bovine Serum (FBS) Made?
Fetal Bovine Serum is a by-product of the cattle industry and is obtained from bovine fetuses.
Biologos’ quality control testing, tests for microbiological abnormalities, such as the presence of bacterial, fungal, and mycoplasma contamination and viruses. Serum is also tested for adventitious agents using modified procedures from the Code of Federal Regulations, Title 9, Section 113.53 (“Requirements for Ingredients of Animal Origin”). Once the absence of contamination has been confirmed and approved, batches of serum are prepared for the packaging and distribution process.
The packaging process begins with serum being thawed under controlled conditions and sterile filtered. Sterile filtration involves the serums being filtered through a series of filters in descending pore size, utilizing 0.1 micron filters for the final filtration step. Filling takes place in a laminar flow hood and a certified clean room to maintain ISO Class 5 conditions. The FBS is aseptically dispensed into gamma irradiated, sterile PETG or HDPE bottles. Filled containers are then labeled, frozen, and maintained at temperatures less than -5°C to preserve the product quality.
FBS Storage and Handling
The Fetal Bovine Serum can be supplied in gamma irradiated, sterile PETG or HDPE bottles and LDPE bioprocess bags (20-100 liter capacity). We recommend that the FBS be stored frozen at a temperature of -5°C to -20°C. Multiple freeze-thaw cycles of the FBS should be avoided as this may lead to deterioration of the product. Always use aseptic techniques when handling the serum and aliquot into sterile containers.
There is a wide range of use for Fetal Bovine Serum. One important application is in the pharmaceutical field, where it is used to research, manufacture and control human and veterinary vaccines. Fetal Bovine Serum is also used extensively for research in Universities and Labs. Fetal Bovine Serum is extensively used in cell culture as a media supplement to culture the growth of cell lines.
Other FBS applications include, but are not limited to: