Fetal Bovine Serum (FBS)

Fetal Bovine Serum (FBS)

Information and Uses

Fetal Bovine (Calf) Serum (FBS or FCS), is a nutrient-rich fluid derived from the blood of bovine fetuses- but does not contain red blood cells or other clotting components. FBS has excellent cell growth characteristics, low endotoxin, low hemoglobin values and is ideal for research that is reliant on growth of cell lines.

Other FBS applications include, but are not limited to:

  • Virology
  • Immunology
  • Pathology

Biologos offers standard and customized serum that is collected from bovine fetuses, prepared, tested, and packaged.

Our quality control testing, tests for microbiological abnormalities, such as the presence of bacterial, fungal, and mycoplasma contamination and viruses. Serum is also tested for adventitious agents using modified procedures from the Code of Federal Regulations, Title 9, Section 113.53 (“Requirements for Ingredients of Animal Origin”). Once the absence of contamination has been confirmed and approved, batches of serum are prepared for the packaging and distribution process.

This process begins with the serum being thawed under controlled conditions and sterile filtered. Sterile filtration involves the serums being filtered through a series of filters in descending pore size, utilizing 0.1 micron filters for the final filtration step. Filling takes place in a laminar flow hood and a certified clean room to maintain ISO Class 5 conditions. The Fetal Bovine Serum is aseptically dispensed into gamma irradiated, sterile PETG or HDPE bottles. Filled containers are then labeled, frozen, and maintained at temperatures less than -5°C to preserve the product quality.

Each batch of serum meets the USDA standards for animal products, Biologos’ standard for raw materials, is traceable to date and collection location, and are processed using:

  • Sterile filtering
  • Irradiation
  • Heat inactivation

Biologos’ serums are trusted and have been used in the advancements of animal health and diagnostic labs globally for more than 40 years.


Fetal Bovine Serum (FBS) is shipped frozen by freezer truck or next day air in insulated containers packed with dry ice.

Storage and Handling

The FBS Media is shipped in gamma irradiated, sterile PETG or HDPE bottles. Biologos recommends that the Fetal Bovine Serum be stored frozen at a temperature of -5oC to -20oC. Multiple freeze-thaw cycles of the serum should be avoided as this may lead to deterioration of the product.

Industry Uses for Fetal Bovine Serum (FBS)

There is a wide range of use for Fetal Bovine Serum. One important application is in the pharmaceutical field, where it is used to research, manufacture and control human and veterinary vaccines. Fetal Bovine Serum is also used extensively for research in Universities and Labs.  Fetal Bovine Serum is extensively used in cell culture as a media supplement to culture the growth of cell lines.

Other FBS applications include, but are not limited to:

  • Virology
  • Immunology
  • Pathology
What is Fetal Bovine Serum?

Fetal Bovine Serum (FBS) is the clear, orange fluid that is obtained from separating blood, sourced from a calf (bovine) fetus, in to its solid and liquid components. Fetal Bovine Serum is among most widely used serum-supplement for cell culture because of it’s valuable growth characteristics. FBS has a very low level of antibodies and contains more growth factors than other types of sera.

What is Fetal Bovine Serum Used For?

Fetal Bovine Serum (FBS) is primarily used as a cell culture media supplement in research and development of pharmaceuticals.

Why is Fetal Bovine Serum Important?

Fetal Bovine Serum is important because of its cell growth characteristics. When it is imperative to have guaranteed growth of cell lines, FBS is typically used.

Who Uses Fetal Bovine Serum?

Fetal Bovine Serum (FBS) is primarily used by laboratories in the pharmaceutical industry as well as University labs.

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