Newborn Calf Serum (NBC or NBCS) is a nutrient-rich fluid derived from the blood of healthy, inspected calves that are less than 14 days old- but does not contain red blood cells or other clotting components. NBC provides many of the same nutrients as fetal bovine serum (FBS) with slightly higher protein and immunoglobulin levels- but less growth factors. NBC can be used as an alternative to FBS in certain applications. Those applications include, but are not limited to:
Biologos offers standard and customized serum that is collected from healthy calves (younger than 14 days old), then prepared, and tested.
Our quality control testing, tests for microbiological abnormalities, such as the presence of bacterial, fungal, and mycoplasma contamination and viruses. Serum is also tested for adventitious agents using modified procedures from the Code of Federal Regulations, Title 9, Section 113.53 (“Requirements for Ingredients of Animal Origin”). Once the absence of contamination has been confirmed and approved, batches of serum are prepared for the packaging and distribution process.
This process begins with the serum being thawed under controlled conditions and sterile filtered. Sterile filtration involves the serums being filtered through a series of filters in descending pore size, utilizing 0.2 micron filters for the final filtration step. Filling takes place in a laminar flow hood and a certified clean room to maintain ISO Class 5 conditions. The NBC Serum is aseptically dispensed into gamma irradiated, sterile PETG or HDPE bottles. Filled containers are then labeled, frozen, and maintained at temperatures less than -5°C to preserve the product quality.
Each batch of serum meets the USDA standards for animal products, Biologos’ standard for raw materials, is traceable to date and collection location, and are processed using:
Biologos’ serums are trusted and have been used in the advancements of animal health and diagnostic labs globally for more than 40 years.
NBC Serum is shipped frozen by freezer truck or next day air in insulated containers packed with dry ice.
NBC Serum can be supplied in gamma irradiated, sterile PETG or HDPE bottles. We recommend that the NBC Serum be stored frozen at a temperature of -5°C to -20°C. Multiple freeze-thaw cycles of the NBC Serum should be avoided as this may lead to deterioration of the product. Always use aseptic techniques when handling the serum and aliquot into sterile containers.
NBC provides many of the same nutrients as fetal bovine serum (FBS) with slightly higher protein and immunoglobulin levels- but less growth factors. NBC can be used as an alternative to FBS in certain applications. Those applications include, but are not limited to: