Newborn Calf Serum


Newborn calf serum (NBC) is collected from healthy, inspected calves that are less than 14 days old. NBC provides many of the same nutrients as fetal bovine serum (FBS) with slightly higher protein levels.

Collection and Processing:


The NBC Serum used by Biologos meets all of the USDA requirements for animal products. All NBC Serum is traceable back to the date and location of collection. In addition, all of the NBC Serum used for processing must meet Biologos’ strict quality requirements for raw material.


Approved lots of raw NBC Serum are thawed under controlled conditions and sterile filtered by a process that uses a series of filters in descending pore size, utilizing 0.2 micron filters for the final filtration step. Filling takes place in a laminar flow hood and clean room certified to maintain ISO Class 5 conditions. The NBC Serum is aseptically dispensed into gamma irradiated, sterile PETG or HDPE bottles. Filled containers are labeled, frozen, and then maintained at temperatures less than -5°C to preserve the product quality.

Quality Control Testing

Microbiological Testing:

Each lot of NBC Serum is tested to confirm the absence of bacterial or fungal contamination.  Each lot of NBC Serum is also tested to confirm the absence of mycoplasma contamination.

Virus Testing:

The NBC Serum is additionally tested for adventitious agents using modified procedures adapted from the Code of Federal Regulations, Title 9, Section 113.53, “Requirements for Ingredients of Animal Origin”.

Storage and Handling

The NBC Serum is shipped in gamma irradiated, sterile PETG or HDPE bottles. Biologos recommends that the NBC Serum be stored frozen at a temperature of -5°C to -20°C. Multiple freeze-thaw cycles of the serum should be avoided as this may lead to deterioration of the product.


NBC Serum is shipped frozen by freezer truck or next day air in insulated containers packed with dry ice.

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