Newborn Calf Serum (NBC or NBCS) is a nutrient-rich fluid derived from the blood of healthy, inspected calves that are less than 14 days old- but does not contain red blood cells or other clotting components. NBC provides many of the same nutrients as fetal bovine serum (FBS) with slightly higher protein and immunoglobulin levels- but less growth factors. NBC can be used as an alternative to FBS in certain applications.
Each batch of serum meets the USDA standards for animal products, Biologos’ standard for raw materials, is traceable to date and collection location, and is processed using:
- Sterile filtering
- Heat inactivation
Those applications include, but are not limited to:
- Cell culture media
- Organ preservation
NBC0600 - Newborn Calf Serum
CSS0400 - Calf Serum
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About Newborn Calf Serum
What is NBC?
Newborn Calf Serum (NBC or NBCS) is a nutrient-rich fluid derived from the blood of healthy, inspected calves that are less than 14 days old- but does not contain red blood cells or other clotting components. NBC provides many of the same nutrients as Fetal Bovine Serum (FBS) with slightly higher protein and immunoglobulin levels- but less growth factors.
NBC is not the same as Fetal Calf Serum (another name for Fetal Bovine Serum or FBS), but it can be used as an alternative to FBS in certain applications.
How is Newborn Calf Serum (NBC) Made?
NBC is a by-product of the cattle industry and is obtained from bovine calves, less than 14 days old.
Biologos’ quality control testing, tests for microbiological abnormalities, such as the presence of bacterial, fungal, and mycoplasma contamination and viruses. Serum is also tested for adventitious agents using modified procedures from the Code of Federal Regulations, Title 9, Section 113.53 (“Requirements for Ingredients of Animal Origin”). Once the absence of contamination has been confirmed and approved, batches of serum are prepared for the packaging and distribution process.
The packaging process begins with serum being thawed under controlled conditions and sterile filtered. Sterile filtration involves the serums being filtered through a series of filters in descending pore size, utilizing 0.2 micron filters for the final filtration step. Filling takes place in a laminar flow hood and a certified clean room to maintain ISO Class 5 conditions. The serum is aseptically dispensed into gamma irradiated, sterile PETG or HDPE bottles. Filled containers are then labeled, frozen, and maintained at temperatures less than -5°C to preserve the product quality.
NBC Storage and Handling
Newborn Calf Serum can be supplied in gamma irradiated, sterile PETG or HDPE bottles. We recommend that the serum be stored frozen at a temperature of -5°C to -20°C. Multiple freeze-thaw cycles of the serum should be avoided as this may lead to deterioration of the product. Always use aseptic techniques when handling the serum and aliquot into sterile containers.
NBC provides many of the same nutrients as Fetal Bovine Serum (FBS) with slightly higher protein and immunoglobulin levels- but less growth factors. The most common applications of NBC include, but are not limited to:
- Cell culture media
- Organ preservation
- Fetal Bovine Serum (FBS) Substitute (in certain applications)