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Acid citrate dextrose (ACD-A) is a solution used for preserving blood and blood products for transfusion. It is a combination of citric acid, sodium citrate, and dextrose, and is used to prevent blood from clotting during storage.
The use of ACD-A as a blood preservative dates back to the early 20th century. In the early 1900s, it was discovered that blood could be stored for longer periods of time if it was mixed with anticoagulants, which prevent the blood from clotting. One of the earliest anticoagulants used was sodium citrate, which was first used in the 1910s.
In the 1930s, researchers began experimenting with the addition of dextrose to blood preservative solutions. Dextrose is a sugar that provides energy to cells, and it was found that adding dextrose to blood preservative solutions could improve the viability of red blood cells during storage.
The first combination of citric acid, sodium citrate, and dextrose, which is now known as ACD-A, was developed in the 1940s. It was found to be an effective blood preservative solution, allowing blood to be stored for up to 21 days without significant deterioration.
Since its development, ACD-A has been widely used in the blood banking industry, as well as in medical research and diagnostics. It is one of several solutions used for preserving blood and blood products for transfusion, and is particularly useful for preserving red blood cells. Today, ACD-A is often used in combination with other anticoagulants and preservatives to optimize the storage and use of blood and blood products.
Acid citrate dextrose (ACD-A) is a solution used to preserve blood and blood products for transfusion. It works by preventing the blood from clotting during storage, which allows the blood to be stored for longer periods of time without significant deterioration.
ACD-A contains three main components: citric acid, sodium citrate, and dextrose. Citric acid and sodium citrate are both anticoagulants, which means they prevent blood from clotting by binding to calcium ions in the blood. Calcium ions are necessary for the formation of blood clots, so by binding to them, citric acid and sodium citrate prevent blood from clotting.
Dextrose, on the other hand, is a sugar that provides energy to cells. When blood is stored, the red blood cells in the blood continue to consume oxygen and produce carbon dioxide, which can cause the pH of the blood to decrease over time. By adding dextrose to the blood preservative solution, the red blood cells are able to produce ATP, a source of energy, which helps to maintain the pH and viability of the cells during storage.
Overall, ACD-A works by preventing blood from clotting and providing energy to red blood cells during storage, which helps to maintain the quality and viability of the blood and blood products. This allows the blood to be stored for longer periods of time without significant deterioration, making it possible to use the blood for transfusion in a variety of medical situations.
Acid citrate dextrose (ACD-A) is primarily used in the blood banking industry for the preservation of blood and blood products for transfusion. However, it also has a few other applications in related industries, including:
Medical research: ACD-A is used in research studies to preserve blood samples for later analysis, as it can prevent blood from clotting and preserve the integrity of the blood components.
Diagnostic testing: ACD-A is sometimes used in diagnostic tests that require fresh blood samples, as it can help to prevent blood from clotting during transport or storage.
Biopharmaceuticals: ACD-A may be used in the production of biopharmaceuticals that require the use of blood or blood products as a raw material, as it can help to maintain the quality and viability of the blood components during storage and processing.
Veterinary medicine: ACD-A may be used in veterinary medicine for the storage and preservation of animal blood and blood products for transfusion.
Overall, ACD-A has limited applications outside of the blood banking industry, but it plays a crucial role in the preservation and storage of blood and blood products for transfusion, which is critical for patient care in a variety of medical situations.
BIOLOGOS is a custom manufacturer of various formulations of Acid Citrate Dextrose, we have the capabilities to take a standard Acid Citrate Dextrose and modify it to your specifications. We bring value to Research and Development initiatives, as well as small batch manufacturing thru full scale production. BIOLOGOS differentiates itself by providing boutique client services and a fully customizable product line for each valued partner.
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